-
Original Article
-
Korean J Med. 2009;77(3):362-366.
- 장기간의 한랭 응집소병 경과 중 발생한 small lymphocytic lymphoma
-
김진영·박우영·이상민·김주연·이형기·김윤정·권기영, , , , , ,
-
- Small lymphocytic lymphoma that developed in a patient with long-standing cold agglutinin disease
-
Jin Young Kim, Woo Young Park, Sang Min Lee, Ju Youn Kim, Hyung Ki Lee, Yun Jung Kim, Ki Young Kwon
-
-
- Abstract
- Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia (AIHA) induced by cold antibodies. CAD constitutes
16~32% of AIHA cases and the causative cold autoantibodies are commonly specific against blood group I or i antigens. CAD is
closely related to lymphoid neoplasia and infections such as Mycoplasma and Epstein-Barr virus (EBV). Primary CAD has a tendency
to develop into malignant lymphoma over its course.
We experienced a case of small lymphocytic lymphoma during the treatment of primary CAD over 11 years. The patient was a
67-year-old man who complained of a neck mass. Node biopsy revealed diffuse neoplastic proliferation of small monotonous lymphoid
cells with polygonal or oval nuclei; these cells were CD20- and CD5-positive.
Follow-up chest and neck computed tomography after treatment with chlorambucil and prednisolone showed partial resolution
and stable disease status for over 2 years. We report a case of small lymphocytic lymphoma that developed in a patient with
long-standing cold agglutinin disease for 11 years and review the literature. (Korean J Med 77:362-366, 2009)
Keywords :Anemia, Hemolytic, Autoimmune, Lymphoma, Non-Hodgkin’s
