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Original Article
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Korean J Med. 2009;77(4):522-526.
- 다발성 뇌신경마비를 보인 B세포 악성림프종 1예
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박진영, 이성은, 유지현, 박종원
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- Secondary involvement of the skull base in malignant B-cell lymphoma
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Jin Young Park, Sung Eun Lee, Ji Hyun Yu, Chong Won Park
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- Abstract
- We report a case of B-cell lymphoma with multiple asymmetrical cranial nerve palsies as the initial presentation. A 70-year-old
woman complained of chin numbness, diplopia, dysarthria, and headache that had developed insidiously over the previous 2
months. The neurological examination showed multiple cranial nerve dysfunction, including right V and left VI nerve palsies. Her
cerebrospinal fluid was normal, while her bone marrow biopsy revealed CD20-positive B-cell lymphoma. Five days after starting
R-CHOP (rituximab-cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy, her cranial nerve palsies and pain
had improved markedly. Twenty days after starting R-CHOP chemotherapy, however, she was rehospitalized due to general worsening
paralysis. In the hospital, the general paralysis progressed rapidly and she lapsed into delirium. No additional treatment was
given based on the directives of her guardian and herself, and she was allowed to leave the hospital for hospice care. (Korean J Med
77:522-526, 2009)
Keywords :Lymphoma, Cranial nerve paralysis
