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Original Article
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Korean J Med. 2009;77(5):643-648.
- 중추신경계와 폐를 침범한 말초 T세포 림프종 1예
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구태연, 박병배, 김혜영, 김원준, 최정혜, 김인순, 이영렬
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- A case of peripheral T-cell lymphoma with central nervous system and bilateral pulmonary involvement
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Tai Yeon Koo, Byeong-Bae Park, Hye Young Kim, Won Jun Kim, Jung Hye Choi, In Soon Kim, Young Yeol Lee
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- Abstract
- Mature T-cell non-Hodgkin’s lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP(ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement.
Keywords :Peripheral T-cell lymphoma, Central nervous system and lung, IMEP, Stem cell transplantation
