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Original Article
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Korean J Med. 2009;77(6):713-715.
- 라미부딘 내성 만성 B형 간염 환자에서 라미부딘과 아데포비어 병합요법
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이한주
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- Lamivudine and adefovir combination therapy in lamivudine-resistant HBeAg-positive chronic hepatitis B patients
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Han Chu Lee
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- Abstract
- The introduction of lamivudine (LAM) has opened a new era for the treatment of chronic hepatitis B (CHB). However, the major drawback of LAM, which currently limits its use as first-line therapy, is the high rate of occurrence of drug resistance. In patients with LAM-resistant CHB, recent long-term findings have indicated that adding adefovir (ADV) to ongoing LAM therapy was more beneficial than switching to ADV alone, because the former showed a diminished rate of resistance to ADV with a well-tolerated safety profile. Above all, the most important strategy for CHB treatment must be to use a potent first-line antiviral with high genetic barriers to resistance in order to prevent the development of multidrug resistance.
Keywords :Chronic hepatitis B, Drug resistance, Lamivudine, Adefovir
