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Original Article
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Korean J Med. 2009;77(1):128-133.
- 젊은 여성에서 발생한 비타민 D 결핍에 의한 골연화증 1예
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명대성, 김민형, 정진욱, 조동혁, 이재혁, 정동진, 정민영
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- A case of osteomalacia due to vitamin D deficiency in a 36-year-old woman
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Dae-Seong Myung, Min Hyung Kim, Jin Ook Chung, Dong Hyeok Cho, Jae Hyuk Lee, Dong Jin Chung, Min Young Chung
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- Abstract
- Osteomalacia is characterized by defective mineralization of bone tissue, which leads to an accumulation of unmineralized bone matrix. The various potential causes of osteomalacia include vitamin D-associated metabolic disorders, absorption disorders, cancer, and drugs. While reports of osteomalacia caused by nutritional deficiency and inadequate sunlight exposure are rare in Korea, we recently experienced a case of osteomalacia due to vitamin D deficiency in a 36-year-old woman. The patient was a strict vegetarian, and over the previous 3 years, she had worked solely at night and reported suffering from multiple bone pain for 6 months. Dual-energy X-ray absorptiometry revealed a T-score of -4.9 and Z-score of -4.5 at the lumbar portion of the spine (L1-4). The serum 25(OH)D level was 7.6 ng/mL, and an iliac bone biopsy showed increased osteoid thickness compatible with osteomalacia. The patient’s symptoms of generalized bone pain improved after vitamin D and calcium supplementation.
Keywords :Osteomalacia, Vitamin D
