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Original Article
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Korean J Med. 2009;77(1):162-167.
- 조기 신경매독에 동반된 막성 신병증 1예
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김종윤, 고정해, 이원동, 문치숙, 김영훈, 강미선, 김양욱
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- Nephrotic syndrome associated with early neurosyphilis
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Jong Yoon Kim, Jung Hae Ko, Won Dong Lee, Chi Sook Moon, Yeong Hoon Kim, Mi Sun Kang, Yang Wook Kim
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- Abstract
- Nephrotic syndrome, hepatitis, and CNS involvement resulting from secondary syphilis are well-documented complications of neurosyphilis. However, the simultaneous occurrence of these complications is rare. The present report describes a 49-year-old male with early neurosyphilis who presented with features of nephritic syndrome and hepatitis. A diagnosis of neurosyphilis was made by CSF study and serologic tests. After the diagnosis of neurosyphilis, nephrotic syndrome and hepatitis were suspected to be factors of the neurosyphilis. A kidney biopsy revealed membranous nephropathy characterized by subepithelial electron dense deposits and diffuse effacement of foot processes. Abdominal ultrasonography showed hepatitis.
The patient was treated with intravenous potassium penicillin G, 4 million units for 2 weeks, and the symptoms and signs resolved after the penicillin therapy. In conclusion, complications experienced by patients with a history of syphilis or syphilis lesions need to be minimized through careful observations and multi-organ treatments.
Keywords :Hepatitis, Nephrotic syndrome, Neurosyphilis, Syphilis
