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Original Article
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Korean J Med. 2009;77(2):441-444.
- 중추신경계 단독 급성기 전환한 만성 골수성백혈병 1예
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이경우, 송무곤, 설영미, 최영진, 신호진, 정주섭, 조군제
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- Isolated central nervous system blast crisis in chronic myeloid leukemia
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Kyung-Woo Lee, Moo-Kon Song, Young-Mi Seol, Young-Jin Choi, Ho-Jin Shin, Joo-Seop Chung, Goon-Jae Cho
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- Abstract
- We report a 39-year-old man with isolated central nervous system (CNS) relapse consisting of a lymphoid blast crisis of Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) who had been treated with imatinib mesylate for a long time. Although complete cytogenetic remission was sustained for 10 months, the patient developed an isolated CNS relapse after controlling leukemia cutis. We started intrathecal chemotherapy and increased the imatinib dose to 600 mg/day. His symptoms improved, and no blasts were detected in the cerebrospinal fluid (CSF). After 2 months, isolated CNS relapse occurred once again. With prolonged intrathecal chemotherapy, the patient became asymptomatic with clear CSF. He remains in complete cytogenetic remission in the bone marrow and peripheral blood, with no CNS relapse.
Keywords :Imatinib mesylate, Chronic myeloid leukemia, Central nervous system, Blast crisis
