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Original Article
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Korean J Med. 2009;77(2):484-488.
- 항 면역글로불린 G4 염색 양성을 보이는 Mikulicz병 1예와 초음파 소견
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김영욱, 권성렬, 주영채, 임미진, 김보묵, 박 원
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- A case of Mikulicz’s disease with positive anti-immunoglobulin G4 staining and unique ultrasonographic findings
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Young Wook Kim, Seong Ryul Kwon, Young Chae Chu, Mie Jin Lim, Bo Mook Kim, Won Park
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- Abstract
- Mikulicz’s disease is an immunoglobulin G4-related systemic disease involving enlargement of the lacrimal and salivary glands that differs substantially from Sjögren’s syndrome. A 45-year-old woman who noticed bilateral swelling in the submandibular region and dry mouth for 6 months was admitted. Ultrasonography of the enlarged glands revealed an irregular, hypoechoic, multilobular mass, and the power Doppler showed that the mass was hypervascular. She had an elevated immunoglobulin G level, positive Schirmer’s I test, and positive unstimulated whole salivary flow test, but was negative for antinuclear, anti-Ro/SS-A, and anti-La/SS-B antibodies. The submandibular gland biopsy showed diffuse infiltration of lymphocytes and plasma cells expressing immunoglobulin G4. We report a patient diagnosed with Mikulicz’s disease involving the infiltration of plasma cells expressing immunoglobulin G4 and unique ultrasonographic findings.
Keywords :Mikulicz’s disease, Immunoglobulin G4, Ultrasonography
