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Original Article
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Korean J Med. 2010;78(1):132-137.
- 필라델피아 양성 급성골수성 백혈병에서 imatinib mesylate 투여로 완전관해 유도된 1예
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장샛별, 배성화, 정혜련, 윤소연, 전언주, 강건우, 류헌모
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- Complete remission of philadelphia chromosome-positive acute myeloid leukemia with imatinib mesylate
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Saet Byul Jang, Sung Hwa Bae, Hye Ryun Jung, So Yeon Yoon, Eon Ju Jun, Gun Woo Kang, Hun Mo Ryoo
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- Abstract
- Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) is a rare disease characterized by a poor prognosis with
resistance to standard chemotherapy. We report a patient with Ph+AML with a minor BCR-ABL-positive mRNA transcript who
achieved a hematologic, cytogenetic, and major molecular complete response after cytarabine-based chemotherapy followed by
imatinib. After more than 6 months of continuous imatinib therapy, the patient is in continuous complete remission. Our results
show that imatinib mesylate is effective in treating Ph+AML. (Korean J Med 78:132-137, 2010)
Keywords :Leukemia, Myeloid, Acute, Philadelphia chromosome, Imatinib mesylate
