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Original Article
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Korean J Med. 2010;78(2):226-230.
- C형 간염의 페그-인터페론과 리바비린 치료 중 생긴 면역 용혈성 빈혈 1예
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유지연, 김창욱, 김진동, 권정현, 장정원, 윤승규, 이창돈
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- Autoimmune hemolytic anemia during PEG-interferon and ribavirin treatment for hepatitis C
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Ji Youn Yu, Chang Wook Kim, Jin Dong Kim, Jeong Hyun Kwon, Jeong Won Jang, Seung Kew Yoon, Chang Don Lee
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- Abstract
- The current best treatment for HCV infection is combination therapy with PEG-interferon and ribavirin. This combination therapy has markedly increased the number of sustained virologic responders but is associated with various side effects, especially hematological abnormalities. We recently experienced a 45-year-old man who developed PEG-interferon induced autoimmune hemolytic anemia (AIHA) and retinal premacular hemorrhage. The worsening hemolysis after ribavirin withdrawal and exclusion of other causes implicated PEG-interferon as the cause of the AIHA. To the best of our knowledge, this is the first case reported from Korea. Treatment with PEG-interferon requires careful follow-up, as it can induce or exacerbate autoimmune diseases. (Korean J Med 78:226-230, 2010)
Keywords :Chronic hepatitis C, Autoimmune hemolytic anemia, Retinal hemorrhage, PEG-interferon
