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Original Article
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Korean J Med. 2010;78(3):386-390.
- 호산구증가증과 PDGFRB 유전자 재배열을 보인 골수종양 1예
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장상언, 강혜진, 장윤환, 이동순, 김현태, 고경원, 양성현
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- A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia
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Sang Eon Jang, Hye Jin Kang, Yoon Hwan Chang, Dong Soon Lee, Hyeon Tae Kim, Kyung Won Koh, Sung Hyun Yang
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- Abstract
- Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib. (Korean J Med 78:386-390, 2010)
Keywords :Myeloid neoplasm, PDGFRB rearrangement, Eosinophilia, Imatinib mesylate
