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Original Article
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Korean J Med. 2010;78(5):645-649.
- 동시적 항암화학방사선요법 시행 후 수술에 성공한 진행성 흉선암종 1예
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임현우, 이명준, 박정호, 박주호, 이선영, 전현정, 조도연
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Division of Allergy, Asthma and Clinical Immunology, Department of Internal Medicine, Chonnnam National University Medical School, Gwangju, Korea
- A case of advanced thymic carcinoma that was resected after concurrent chemoradiotherapy
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Hyun Woo Lim, Myung Jun Lee, Jeong Ho Park, Joo Ho Park, Sun Young Lee, Hyun Jung Jun, Do Yeun Cho
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전남대학교 의과대학 알레르기내과
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- Abstract
- Thymic carcinoma is a rare, but aggressive, tumor that often metastasizes to regional lymph nodes and distant sites and often has a poor prognosis. Although the efficacy of induction therapy in thymic carcinoma is unclear, we report the clinical course of a patient who underwent complete surgical resection after effective induction chemoradiotherapy. A 66-year-old man was diagnosed with a poorly differentiated thymic carcinoma (Masaoka stage III). The tumor was considered unresectable due to sternal invasion and surrounding fat infiltration. Two cycles of chemotherapy, consisting of paclitaxel (180 mg/m2 on D1) and cisplatin (80 mg/m2 on D1) combined with mediastinal radiotherapy (total 50 Gy) were performed concurrently; the mass decreased to a resectable size. Subsequently, he received adjuvant chemotherapy and adjuvant radiation therapy. He is currently alive and ambulatory and has remained disease-free for 19 months. This case demonstrates that induction chemoradiotherapy with paclitaxel and cisplatin may be tolerated and useful for patients with locally advanced thymic carcinoma. (Korean J Med 78:645-649, 2010)
Keywords :Thymic carcinoma, Paclitaxel, Cisplatin, Neoadjuvant chemoradiotherapy, Surgery
