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Original Article
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Korean J Med. 2010;78(6):741-746.
- 메트로놈 항암요법을 통하여 완전관해를 경험한 진행성 간세포암 2예
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전연주, 배시현, 정문경, 최종영, 윤승규, 천호종, 최병길
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Division of Allergy, Asthma and Clinical Immunology, Department of Internal Medicine, Chonnnam National University Medical School, Gwangju, Korea
- Two cases of advanced hepatocellular carcinoma achieving a complete response with metronomic chemotherapy via the hepatic artery via the hepatic artery
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Yeon Joo Chun, Si Hyun Bae, Mun Kyoung Chung, Jong Young Choi, Seung Kew Yoon, Ho Jong Chun, Byung Gil Choi
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전남대학교 의과대학 알레르기내과
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- Abstract
- Advanced hepatocellular carcinoma (HCC) has a poor prognosis and few effective therapies. Recently, low-dose antiangiogenic
(also called metronomic) chemotherapy has been tested in patients with advanced HCC. Here, we report two patients with advanced
HCC who showed a good response after metronomic chemotherapy. The first was a 54-year-old man who was diagnosed with advanced
HCC with lung metastasis. After three cycles of metronomic chemotherapy, the size of tumor and pulmonary metastatic lesions
had decreased markedly on follow-up computed tomography. The second was a 54-year-old woman who was diagnosed with
HCC with portal vein thrombosis. Metronomic therapy was performed. After 9 months, tumor enhancement in the arterial phase
had disappeared completely, and the portal vein thrombus was decreased slightly. Metronomic therapy is an interesting treatment
option for patients with advanced HCC. More clinical data and studies are needed to confirm this result. (Korean J Med 78:741-746,
2010)
Keywords :Metronomic chemotherapy, Carcinoma, Hepatocellular
