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Original Article
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Korean J Med. 2011;80(2):268-272.
- De novo t(11:19) 염색체 전위를 보인 급성전골수성백혈병 1예
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조성연1, 김주연1, 허주연1, 이성진1, 한치화1, 이제훈2
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- A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation
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Sung-Yeon Cho1, Ju-Youn Kim1, Ju-Yeon Heo1, Seong-Jin Lee1, Chi-Wha Han1, Je-Hoon Lee2
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- Abstract
- Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARα) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
Keywords :Acute promyelocytic leukemia, Chromosomal translocation, Molecular pathology
