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Case Report
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Korean J Med. 2014;86(2):242-246. Published online February 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.2.242
- 동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후
골수 무형성증 1예
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윤현화1, 홍준식1, 김수영1, 이동민1, 박진희1, 안정열2, 이재훈1
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1가천대학교 의학전문대학원 내과
2가천대학교 의학전문대학원 진단검사의학과
- Acute Myeloid Leukemia with Persistent Marrow Aplasia after Chemotherapy
Treated with Reduced-Intensity Allogeneic Stem Cell Transplantation
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Hyunhwa Yoon1, Junshik Hong1, Suyoung Kim1, Dongmin Lee1, Jinny Park1, Jeong Yeal Ahn2, Jae Hoon Lee1
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1Departments of Internal Medicine, Gachon University School of Medicine, Incheon, Korea
2Departments of Laboratory Medicine, Gachon University School of Medicine, Incheon, Korea
- Corresponding author: Junshik Hong ,Tel: +82-32-460-3229, Fax: +82-32-460-3233, Email: alertjun@hanmail.net
- Received: March 18, 2013; Revised: May 2, 2013 Accepted: August 12, 2013.
- 급성 골수성 백혈병에서 고용량 항암화학요법 후 발생하는 지속성 골수 무형성증은 높은 이환율과 사망률을 나타낼 수 있는 매우 드문 합병증으로 더욱이 감염까지 동반한 경우는 일반적으로 조혈모세포이식의 금기이나 전문적인 감염 치료를 병행하면서 비골수억제성 전처치로 조혈모세포이식을 적극 고려해야 한다.
߽ɾ :급성 골수성 백혈병; 조혈모세포이식; 무형성
빈혈; 호중구 감소증; 항암화학요법
- Abstract
- Persistent bone marrow aplasia after intensive chemotherapy is uncommon, but is one of the fatal complications in patients with acute myeloid leukemia (AML). Although allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be contraindicated for patients who have hematologic diseases with serious infections, such as bacterial septicemia or invasive fungal diseases, combined with prolonged neutropenia due to frequent morbidity and mortality, such risks can be overcome by non-myeloablative conditioning and best supportive care. Here, we report an AML patient with persistent marrow aplasia after induction therapy, treated successfully with reduced-intensity allogeneic HSCT despite severe bacterial and fungal infections. (Korean J Med 2014;86:242-246)
Keywords :Acute myeloid leukemia, Stem cell transplantation, Aplastic anemia, Neutropenia, Chemotherapy
