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Case Report
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Korean J Med. 2014;86(2):247-252. Published online February 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.2.247
- 류마티스관절염이 동반된 고전형 카포시육종의 에토포사이드
치료 1예
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최난영1, 박승아1, 한보람1, 김호영1, 민수기2, 김효정1, 장대영1
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1한림대학교 의과대학 내과학교실
2한림대학교 의과대학 병리학교실
- A Case of Etoposide Therapy in a Patient Newly Diagnosed with Classic Kaposi's
Sarcoma and Rheumatoid Arthritis
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Nan Young Choi1, Seung Ah Park1, Bo Ram Han1, Ho Young Kim1, Soo Kee Min2, Hyo Jung Kim1, Dae Young Zang1
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1Departments of Internal Medicine, Hallym University College of Medicine, Anyang, Korea
2Departments of Pathology, Hallym University College of Medicine, Anyang, Korea
- Corresponding author: Hyo Jung Kim ,Tel: +82-31-380-3704, Fax: +82-31-386-2269, Email: hemonc@hallym.or.kr
- Received: April 27, 2013; Revised: July 4, 2013 Accepted: September 1, 2013.
- 본 저자들은 류마티스관절염을 처음 진단받고 면역저하의 증거가 없으며 HHV-8 음성이며 전신상태가 좋지 않은 고령의 환자에서 전신 피부에 발생한 4병기 고전형 카포시육종을 진단하였고 지속적인 저용량 경구 에토포사이드 단독요법으로 좋은 임상경과를 얻은 증례가 있어 보고하는 바이다.
߽ɾ :카포시육종; 사람면역결핍바이러스; 사람헤르
페스바이러스 8; 에토포사이드; 류마티스관절염
- Abstract
- Kaposi's sarcoma typically occurs in immunocompromised patients, especially those with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) and human immunodeficiency virus (HIV) may play important roles in the development of Kaposi's sarcoma. We report the case of a 75-year-old male who presented with progressive multiple purplish papules and nodules on the skin for 3 months. Social and past medical histories seemed incompatible with an immunesuppressed condition and tests for HIV antibodies and HHV-8 were negative. He was newly diagnosed with rheumatoid arthritis, according to the 2010 ACR-EULAR criteria. Typical findings of Kaposi's sarcoma were confirmed by biopsy. After treatment with metronomic oral etoposide 25 mg once daily for 9 months, the skin lesions had almost resolved with no serious complication. Thus, we report a rare case of Kaposi’s sarcoma developing in a patient with newly diagnosed rheumatoid arthritis who showed a good response to oral etoposide. (Korean J Med 2014;86:247-252)
Keywords :HIV, Sarcoma, Kaposi, Herpesvirus 8, Human, Etoposide, Arthritis, Rheumatoid
