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Special Review
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Korean J Med. 2014;86(6):655-663. Published online June 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.6.655
- Helicobacter pylori 연관 소화성궤양
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서승인, 김학양
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한림대학교 의과대학 강동성심병원 소화기내과
- Helicobacter pylori-related Peptic Ulcer Disease
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Seung In Seo, Hak Yang Kim
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Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
- Corresponding author: Hak Yang Kim ,Tel: +82-2-2224-2113, Fax: +82-2-2224-2647, Email: bacter@hallym.or.kr
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߽ɾ :헬리코박터 파일로리; 소화성궤양; 역학; 치료
- Abstract
- Although the worldwide prevalence of Helicobacter pylori (H. pylori) infection has decreased, peptic ulcer disease (PUD) remains prevalent due to increased usage of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin. In recent years, the prevalence of H. pylori infection in PUD cases and the distribution of PUD have changed in Korea. The incidence of idiopathic H. pylori-negative ulcers has increased, and research is needed to determine the cause of these idiopathic ulcers. The eradication of H. pylori infection decreases PUD recurrence, and plays a crucial role in the treatment of PUD. The H. pylori test-and-treat strategy is beneficial for patients starting NSAIDs and long-term aspirin users with a history of bleeding ulcers. Although the H. pylori eradication rate is declining steadily due to antibiotic resistance, especially to clarithromycin, current guidelines still recommend standard triple therapy, including a proton pump inhibitor, amoxicillin, and clarithromycin, as a first-line therapy. Recently, various treatment regimens, including sequential or concomitant therapies, have been developed in an attempt to overcome the low eradication rate observed with standard triple therapy. The aim of this article is to review recent trends in H. pylori-related PUD, focusing on epidemiology and treatment strategies. (Korean J Med 2014;86:655-663)
Keywords :Helicobacter pylori peptic ulcer, Epidemiology, Treatment
