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Special Review
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Korean J Med. 2014;86(6):664-672. Published online June 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.6.664
- 비스테로이드소염제 관련 소화성 궤양의 최신지견
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최동욱1, 박성철1, 전훈재2
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1강원대학교 의학전문대학원 내과학교실
2고려대학교 의과대학 내과학교실
- Update on NSAIDs Related Peptic Ulcers
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Dong Wook Choi1, Sung Chul Park1, Hoon Jai Chun2
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1Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea
2Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
- Corresponding author: Hoon Jai Chun ,Tel: +82-2-920-6555, Fax: +82-2-953-1943, Email: drchunhj@chol.com
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߽ɾ :비스테로이드소염제; 소화성 궤양, 치료; 예방
- Abstract
- Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic, and anti-inflammatory properties and are widely used for treating musculoskeletal and cardiovascular diseases. Notwithstanding these therapeutic efficacies, gastrointestinal toxicity is the major health problem associated with NSAID use. NSAID-related peptic ulcers are a well-known complication due to direct mucosal injury and cyclooxygenase inhibition. Risk factors for NSAID-related peptic ulcers include a prior history of peptic ulcer; age > 65 years; high-dose NSAID therapy; and concurrent use of aspirin (including low dose), corticosteroids, or anticoagulants. In addition, Helicobacter pylori infection is an independent risk factor; therefore, eradication therapy is recommended in high-risk patients using NSAIDs. Currently, misoprostol, H2-receptor antagonists, proton pump inhibitors, and COX-2 selective inhibitors are used to prevent and treat NSAID-related peptic ulcers. Further, strategic approaches are required through appropriate NSAID use and risk factor stratification to prevent NSAID-related peptic ulcers and associated complications. (Korean J Med 2014;86:664-672)
Keywords :Non-steroidal anti-inflammatory drugs, Peptic ulcer, Treatment, Prevention
