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Special Review
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Korean J Med. 2015;88(1):22-26. Published online January 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.1.22
- 변비 약물 치료의 지침 – 어떤 약제를, 언제 사용해야 하는가?
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신정은1, 홍경섭2, 정기욱3, 이태희4, 이봉은5, 박선영6, 홍성노7, 김성은8, 박경식9, 최석채10, 대한소화기기능성질환·운동학회 변비 및 항문직장기능 연구회
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1단국대학교 의과대학 내과학교실
2서울대학교 의과대학 내과학교실
3울산대학교 의과대학 소화기내과학교실
4순천향대학교 의과대학 소화기연구소
5부산대학교 의과대학 내과학교실
6전남대학교 의과대학 내과학교실
7성균관대학교 의과대학 내과학교실
8이화여자대학교 의학전문대학원 내과학교실
9계명대학교 의과대학 내과학교실
10원광대학교 의과대학 내과학교실 및 소화기질환 연구소
- Guidelines for the Use of Laxatives - Which Laxatives, When?
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Jeong Eun Shin1, Kyoung Sup Hong2, Kee Wook Jung3, Tae Hee Lee4, Bong Eun Lee5, Seon-Young Park6, Sung Noh Hong7, Seong-Eun Kim8, Kyung Sik Park9, Suck Chei Choi10, Constipation Research Group of the Korean Society of Neurogastroenterology and Motility
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1Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea
2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
3Department of Gastroenterology, University of Ulsan College of Medicine, Seoul, Korea
4Institute for Digestive Research, Soonchunhyang University College of Medicine, Seoul, Korea
5Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
6Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
7Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
8Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea
9Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
10Department of Internal Medicine and Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea
- Corresponding author: Suck Chei Choi ,Tel: +82-63-859-2563, Fax: +82-63-855-2025, Email: medcsc@wmc.wonkwang.ac.kr
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- Abstract
- To manage chronic constipation, dietary and lifestyle modifications should be tried before pharmacological intervention. Although there is no standardized treatment guideline for medical practice, the key considerations in the choice of laxative include the treatment duration, dosing schedule, type of agent, effects and side effects of the agent, and cost. The first-line treatment is a bulking or osmotic laxative. If the patient is still symptomatic, the physician can add or switch to other laxatives. Next, prucalopride, a highly selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist, could be considered. If the constipation is refractory to combination therapy with conventional laxatives and prucalopride, patients should be referred for further evaluation, including physiological testing.
Keywords :Constipation, Laxatives
