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Case Report
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Korean J Med. 2015;88(1):78-82. Published online January 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.1.78
- 항정신병 약제 치료 중 동반된 프로락틴 분비 뇌하수체 거대선종 치료 1예
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김봉선, 김주성, 류형규, 박진웅, 현선아, 강제욱, 최용준
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아주대학교 의과대학 내분비대사내과학교실
- A Case of Pituitary Macroadenoma Concurrently Diagnosed in a Patient Undergoing Antipsychotic Treatment
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Bong Sun Kim, Joo Sung Kim, Hyong Kyu Ryu, Jin Woong Park, Sun A Hyun, Je Wook Kang, Yong Jun Choi
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Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea
- Corresponding author: Yong Jun Choi ,Tel: +82-31-219-4491, Fax: +82-31-219-4497, Email: colsmile@hanmail.net
- Received: January 23, 2014; Revised: May 26, 2014 Accepted: June 27, 2014.
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- Abstract
- Antipsychotics are the drug of choice for patients with schizophrenia, but they can induce hyperprolactinemia and growth of pituitary adenomas by blocking dopamine 2 receptors in the pituitary gland. In contrast, the medical treatment for a prolactinoma is a dopamine agonist. Therefore, managing a patient concurrently diagnosed with a prolactinoma and psychosis is challenging. We describe a patient with schizophrenia who was diagnosed with a prolactinoma. We changed his neuroleptic to quetiapine and prescribed bromocriptine for the prolactinoma. As a result, the patient was successfully treated with a dopamine agonist and antipsychotic without psychotic exacerbation. Our case suggests that dopamine agonists can be administrated to patients with schizophrenia and a prolactinoma without adversely affecting their psychopathological status.
Keywords :Prolactinoma, Bromocriptine, Antipsychotic agents
