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Case Report
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Korean J Med. 2015;88(2):231-235. Published online February 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.2.231
- 식도암 환자에서 발생한 항이뇨 호르몬 부적절 분비 증후군 1예
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이소연, 신성호, 이재혁, 안재성, 도병주, 장근두, 송헌호
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한림대학교 의과대학 강동성심병원 내과
- Case of Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient with Esophageal Cancer
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SoYon Rhee, SungHo Shin, JaeHyuk Lee, JaeSung An, ByongJoo Do, Geundoo Jang, Hunho Song
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Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
- Corresponding author: Hunho Song ,Tel: +82-2-2224-2691, Fax: +82-2-478-6925, Email: hunhos@hallym.or.kr
- Received: February 22, 2014; Revised: April 7, 2014 Accepted: June 13, 2014.
- 저자들은 식도암의 5-FU와 시스플라틴을 사용한 항암 방사선 치료에서 유발된 항이뇨 호르몬 부적절 분비 증후군의 증례를 국내에서 처음으로 보고하는 바이다. 본 증례에서와 같이 시스플라틴의 반복 사용이 이러한 증후군을 유발 또는 악화시킬 수 있다고 생각된다. 그러므로 시스플라틴을 처음 사용한 후에 저나트륨 혈증이 발생하지 않더라도 다음 치료 후 암에 대한 치료와 아울러 항이뇨 부적절 분비 증후군의 발생 가능성에 대한 주의 및 대비가 요구된다. 나아가 식도암 자체가 이러한 증후군을 유발시킬 수 있는지에 대해서도 연구가 필요하다.
߽ɾ :항이뇨 호르몬 부적절 분비 증후군; 식도암; 시스플라틴; 방사선 치료
- Abstract
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may be observed in various types of cancer, but is mainly seen in small-cell carcinoma. It can also be caused by several chemotherapeutic agents. However, it is a very rare phenomenon in esophageal cancer or its treatment. We report here on a case of SIADH related to esophageal cancer treatment. A 55-year-old man received chemoradiotherapy (CRT) for esophageal cancer. After receiving CRT for 5 days, he complained of nausea, dizziness, and general weakness, and his sodium level had dropped to 107 mEq/L. His volume status was clinically euvolemic and there were no edema or pigmentation. After hypertonic saline infusion, the sodium level increased and the symptoms improved. There have been several reports of SIADH associated with malignancies or chemotherapy agents. However, to the best of our knowledge, this is the first Korean case of SIADH associated with esophageal cancer that occurred after cisplatin treatment.
Keywords :Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), Esophageal cancer, Cisplatin, Chemoradiotherapy
