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Case Report
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Korean J Med. 2015;88(3):288-292. Published online March 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.3.288
- 페그 인터페론과 리바비린 투여 후 발생한 돌발성 난청 1예
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박건우1, 박형열1, 방의경2, 조준호1, 정민웅1, 오송희1
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1부산보훈병원 내과
2부산보훈병원 이비인후과
- Sudden Deafness in a Patient with Chronic Hepatitis C Treated with Peginterferon and Ribavirin Combination Therapy
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Gun Woo Park1, Hyoung Yeol Park1, Eui Kyeong Bang2, Jun Ho Jo1, Min Woong Jeong1, Song Hee Oh1
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1Departments of Internal Medicine, Busan Veterans Hospital, Busan, Korea
2Departments of Otolaryngology, Busan Veterans Hospital, Busan, Korea
- Corresponding author: Gun Woo Park ,Tel: +82-51-601-6000, Fax: +82-51-601-6339, Email: z-zone13@hanmail.net
- Received: February 27, 2014; Revised: April 7, 2014 Accepted: August 28, 2014.
- 62세 여자 환자에서 만성 C형 간염으로 페그 인터페론과 리바비린 병합 치료를 하고 치료 종결 2주 후 돌발적 난청이 발생하여 이비인후과에 입원했다. 전신적 스테로이드 치료를 2주간 시행했으나 큰 호전을 보이지 않았고 퇴원 후 약 1년간 외래 경과관찰 중 서서히 청력이 회복되는 증례를 경험했기에 문헌고찰과 함께 보고하는 바이다.
߽ɾ :만성 C형 간염; 페그 인터페론 알파 2a; 리바비린; 돌발성 난청
- Abstract
- Combined peginterferon and ribavirin therapy for chronic hepatitis C is associated with several adverse side effects, but sudden deafness is uncommon. Here we report the case of a 62-year-old female with chronic hepatitis C (genotype 1b) who developed sud-den deafness after completing 12 months of treatment with peginterferon α2a (180 μg/week) and ribavirin (1,000 mg/day). Pure-tone audiometry revealed a right-sided sensorineural hearing loss, which did not respond to 2 weeks of systemic corticosteroid therapy. Six months after the end of treatment for chronic hepatitis C, her qualitatively determined hepatitis C virus RNA level was 121,000 IU/mL. Following therapeutic failure, the patient was observed without retreatment for chronic hepatitis C or her hearing loss for a period of 12 months, during which time her hearing recovered almost completely.
Keywords :Hepatitis C, Chronic, Peginterferon alfa-2a, Ribavirin, Hearing loss, Sudden
