The Korean Journal of Internal Medicine

Special Review: Korean J Med. 2015;88(5):518-524. Published online May 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.5.518; 침습성 진균 감염증과 약제 내성; 김어진, 정숙인; 전남대학교 의과대학 내과학교실; Invasive Fungal Infections in the Era of Antifungal Resistance; Uh Jin Kim, Sook-In Jung; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea; Corresponding author: Sook-In Jung ,Tel: +82-62-220-6502, Fax: +82-62-225-8578, Email: sijung@chonnam.ac.kr

Abstract: Invasive fungal diseases are an important cause of morbidity and mortality in both immunocompromised and immunocompetent patients. The recent introduction of new antifungal agents seemed to open a new era for the treatment of invasive fungal infections. However, widespread use of prophylactic and therapeutic antifungal agents has lead to the emergence of antifungal resistance and potentially compromises their clinical utility. By understanding the mechanisms of drug resistance, new strategies can be utilized to minimize the emergence of drug resistance and to promote the development of innovative therapeutic approaches. In the meantime, close monitoring of antifungal resistance and its evolution is warranted in a clinical setting given the limited repertoire of antifungal drugs.

Keywords :Antifuangals, Resistance, Invasive fungal infection