| Profiles of infectious complications on the outcomes for the recipients of allogeneic hematopoietic stem cell transplantation |
|
Ji Young Rhee, Eun Hee Jang, Seung Tai Kim, Yu Mi Wi, Kyong Mok Son, Hae Suk Cheong, Hyun Kyun Ki, Won Sup Oh, Ki Hyun Kim, Chul Won Jung, Won Seog Kim, Keunchil Park, Kyong Ran Peck, Jae Hoon Song |
|
고려대학교 의과대학 내과학교실 |
| 원저 : 동종 조혈 모세포 이식 환자에서 감염증의 양상에 대한 고찰 |
|
이지영, Eun Hee Jang, Seung Tai Kim, Yu Mi Wi, Kyong Mok Son, Hae Suk Cheong, Hyun Kyun Ki, Won Sup Oh, Ki Hyun Kim, Chul Won Jung, Won Seog Kim, Keunchil Park, Kyong Ran Peck, Jae Hoon Song |
|
|
|
|
|
|
| Abstract |
Background : We wanted to investigate the effect of infectious complications on the outcome of patients who received allogeneic hematopoietic stem cell transplantation (HSCT), and we determined the risk factors for predicting infectious complication and the mortality in allogeneic HSCT recipients.
Methods
: We enrolled all the patients who underwent allogeneic HSCT at Samsung Medical Center from February 1996 to October 2003.
Results
: A total of 139 patients were enrolled. A total of 450 infectious episodes were observed in 131 allogeneic recipients (90.8%). Infectious complications occurred in the allogeneic recipients [3.243.00 episodes/patient]. Microbiologically documented infection (MDI), clinically documented infection (CDI), and unknown fever (UF) accounted for 41.6%, 34.0% and 24.4%, respectively, of the total infections. Pneumonia (15.1%) was the most common infection. Among the 187 MDIs, bacterial infection, viral infection and fungal infection accounted for 50.3%, 39.6%, and 7.5%, respectively. Twelve of 24 deaths in the late post transplantation period were related with infection. The statistically significant risk factors for infection related to mortality, by multivariate analysis, were the underlying disease risk, the duration of neutropenia, the failure of stem cell engraftment, acute GVHD, MDI, UF, the number of infectious episodes, bacteremia, fungemia, pneumonia, genitourinary tract infections, S. aureus, E. coli, Pseudomonas spp., Aspergillus spp., Non-albicans candida and CMV diseases.
Conclusions
: The incidence of fungal infections was still low in our institute, even though prophylaxis for fungal infections was not applied, except for gargling with nystatin. In addition, most of them were non-albican Candida and Aspergillus species. Therefore, routine fluconazole prophylaxis may not be needed in our institute.(Korean J Med 72:200-208, 2007)
Key Words : Hematopoietic stem cell transplantation, Infections, Mortality |
| Key Words:
Hematopoietic stem cell transplantation, Infections, Mortality |
|
PDF Links
Full text via DOI
Download Citation
