| A case of insulin autoimmune syndrome that developed after topiramate anti-obesity medication |
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Ji-Hyung Hong, Eun-Joo Lim, Jung-Min Lee, Sang-Ah Chang |
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| 증례 : 항비만제 복용 후 발생한 인슐린 자가면역 증후군 1예 |
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홍지형.임은주.이정민.장상아 , Eun-Joo Lim, Jung-Min Lee, Sang-Ah Chang |
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| Abstract |
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Insulin autoimmune syndrome (IAS) is characterized by insulin autoantibodies, hyperinsulinemia, and hypoglycemic symptoms in patients who have not received exogenous insulin injections. A 38-year-old female was admitted complaining of postprandial dizziness and hunger after one month on topiramate for the purpose of losing weight. When her hypoglycemic symptoms were present, her serum glucose level was 42 mg/dL, insulin 227.4 μIU/mL, and C-peptide 5.26 ng/mL, with positive insulin autoantibodies (72.1%) and an increased proinsulin level. Her HLA type was HLA-DR4 positive. Topiramate is both an anticonvulsant and migraine prophylactic. Taking advantage of its adverse effect of weight loss, it has been used as an anti-obesity drug. In addition, it has been reported to induce hypoglycemia, although the mechanism of this has not been determined. Here, we report a case of IAS that occurred after topiramate administration. (Korean J Med 75:S866-S869, 2008) |
| Key Words:
Insulin autoimmune syndrome; Topiramate; Hypoglycemia |
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